Genetic markers of severe preeclampsia
نویسندگان
چکیده
In modern medicine, close attention is paid to the issues of reducing maternal morbidity and mortality, structure which hypertensive disorders gestation, especially preeclampsia, make a significant contribution. The complex pathomorphological mechanisms underlying etiopathogenesis this pregnancy complication occur long before manifestation pronounced clinical signs, complicates early diagnosis preeclampsia determines relevance search for new preeclampsia-specific markers, including genetic ones. aim study: To evaluate associations polymorphic markers GWAS-significant candidate genes hypertension with development severe preeclampsia. Materials methods: sample women moderate included 145 individuals, 72 patients. All subjects underwent genotyping four loci (rs8068318 TBX2, rs2681472 ATP2B1, rs4387287 OBFC1, rs1799945 HFE). empirical distribution genotypes its correspondence theoretically expected one within framework Hardy-Weinberg regularity are studied. Logistic regression analysis was carried out were studied according models, introduction corrections covariates. Results: It found that rs8068318 TBX2 gene associated in allelic (OR = 0.45; рperm 0.004), additive 0.46; 0.002), dominant 0.42; 0.005) recessive 0.22; 0.04) models. locus localized region hypersensitivity DNase, DNA regulatory motifs transcription factors, histone tags marking enhancers promoters various organs tissues, negatively regulates expression TBX2-AS1 adipose tissue brain, thyroid gland, level alternative splicing RP11-332H18.5 tissues. Conclusion: marker population Central Chernozem Russian Federation.
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ژورنال
عنوان ژورنال: ??????? ?????????? ?????????????? ????????????
سال: 2022
ISSN: ['2658-6533']
DOI: https://doi.org/10.18413/2658-6533-2022-8-3-0-4